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 SHORT COMMUNICATION
Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 370-372

Effect of some serotonergic agents on lithium-pilocarpine model of status epilepticus in rats



Correspondence Address:
S B Kasture


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Objectives: To study the effect of some serotonerigc agents on lithium-pilocarine model of status epilepticus in rats. Methods: Pilocarpine (30 mg/kg, s.c.) was given 24 hrs after administration of lithium sulphate (3 meq/ kg, i.p.) to induce seizures. The test drugs were given 45 minutes prior to administration of pilocarpine, except pCPA which was given 72 hrs before lithium. The effect on severity of convulsions was observed. Results: Dexfenfluramine and cisapride significantly potentiated the seizure, whereas buspirone, mianserine, cyproheptadine, fluoxetine, ondanstron and pCPA significantly protected animals from the lithium pilocarpine induced seizures. Conclusion: Thus the study suggests that the blockade of postsynaptic 5-HT receptors and inhibition of serotonergic transmission inhibit lithium-pilocarpine-induced seizure.






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