IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3290 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded170    
    Comments [Add]    

Recommend this journal


Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 370-372

Effect of some serotonergic agents on lithium-pilocarpine model of status epilepticus in rats

Correspondence Address:
S B Kasture

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To study the effect of some serotonerigc agents on lithium-pilocarine model of status epilepticus in rats. Methods: Pilocarpine (30 mg/kg, s.c.) was given 24 hrs after administration of lithium sulphate (3 meq/ kg, i.p.) to induce seizures. The test drugs were given 45 minutes prior to administration of pilocarpine, except pCPA which was given 72 hrs before lithium. The effect on severity of convulsions was observed. Results: Dexfenfluramine and cisapride significantly potentiated the seizure, whereas buspirone, mianserine, cyproheptadine, fluoxetine, ondanstron and pCPA significantly protected animals from the lithium pilocarpine induced seizures. Conclusion: Thus the study suggests that the blockade of postsynaptic 5-HT receptors and inhibition of serotonergic transmission inhibit lithium-pilocarpine-induced seizure.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow