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Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 354-357

Decreased phosphatidate phosphohydrolase activity in the liver of rats exposed to nicotinic acid, clofibrate and gemfibrozil

Correspondence Address:
Haghighi Bahram

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate whether nicotinic acid, gemfibrozil and clofibrate exert their hypolipidemic effect by changing the activity of hepatic phosphatide phosphohydrolase (PAP). Methods: Male Wistar rats were intraperitoneally treated with one of the following: nicotinic acid, clofibrate, gemfibrozil, corresponding vehicle. All animals were given corn oil ( p.o.) 2 h before injection. They were sacrificed at different time intervals and PAP enzyme activity was measured in liver homogenate. Serum triacylglycerol and cholesterol levels were also estimated. Results: Nicotinic acid inhibited PAP activity 35% with simultaneous decrease in serum triacylglycerol (29%) and cholesterol (22%) concentrations. Clofibrate also inhibited PAP activity (31%) with parallel decline in the concentrations of triacylglycerol (26%) and cholesterol (19%). Similar patterns were observed in rats injected with gemfibrozil in which the fall in PAP activity, triacylglycerol and cholesterol concentrations were 17%, 43% and 12% respectively. Conclusion: Hypolipemic effects of these compounds are, at least in part, resulted from inhibition of hepatic PAP activity, a key enzyme in the lipid metabolism.


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