IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3294 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1234    
    Printed92    
    Emailed0    
    PDF Downloaded101    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 354-357

Decreased phosphatidate phosphohydrolase activity in the liver of rats exposed to nicotinic acid, clofibrate and gemfibrozil



Correspondence Address:
Haghighi Bahram


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To investigate whether nicotinic acid, gemfibrozil and clofibrate exert their hypolipidemic effect by changing the activity of hepatic phosphatide phosphohydrolase (PAP). Methods: Male Wistar rats were intraperitoneally treated with one of the following: nicotinic acid, clofibrate, gemfibrozil, corresponding vehicle. All animals were given corn oil ( p.o.) 2 h before injection. They were sacrificed at different time intervals and PAP enzyme activity was measured in liver homogenate. Serum triacylglycerol and cholesterol levels were also estimated. Results: Nicotinic acid inhibited PAP activity 35% with simultaneous decrease in serum triacylglycerol (29%) and cholesterol (22%) concentrations. Clofibrate also inhibited PAP activity (31%) with parallel decline in the concentrations of triacylglycerol (26%) and cholesterol (19%). Similar patterns were observed in rats injected with gemfibrozil in which the fall in PAP activity, triacylglycerol and cholesterol concentrations were 17%, 43% and 12% respectively. Conclusion: Hypolipemic effects of these compounds are, at least in part, resulted from inhibition of hepatic PAP activity, a key enzyme in the lipid metabolism.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow