| RESEARCH PAPER
|Year : 1999 | Volume
| Issue : 5 | Page : 350-353
Effect of fluoxetine on increasing-current electroshock seizures (ICES) in mice
Marwah Renuka, Pal N Shanthi, KK Pillai
Objective: To study the anticonvulsant effect of fluoxetine against electrically induced seizures.
Methods: The anticonvulsant effect of fluoxetine in different doses following both acute and chronic administrations, was assessed in a modified version of increasing-current electroshock seizure test in mice. The increase in current required to induce the tonic hindlimb extension (seizure threshold current) was observed as a parameter of anticonvulsant effect.
Results: Fluoxetine produced significant anticonvulsant effects in some of the doses studied. Significant increase in seizure threshold current was observed after 7, 14 and 21 days of treatment.
Conclusion: Fluoxetine exhibited anticonvulsant activity against ICES induced seizures.
Source of Support: None, Conflict of Interest: None