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Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 350-353

Effect of fluoxetine on increasing-current electroshock seizures (ICES) in mice

Correspondence Address:
Marwah Renuka

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Source of Support: None, Conflict of Interest: None

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Objective: To study the anticonvulsant effect of fluoxetine against electrically induced seizures. Methods: The anticonvulsant effect of fluoxetine in different doses following both acute and chronic administrations, was assessed in a modified version of increasing-current electroshock seizure test in mice. The increase in current required to induce the tonic hindlimb extension (seizure threshold current) was observed as a parameter of anticonvulsant effect. Results: Fluoxetine produced significant anticonvulsant effects in some of the doses studied. Significant increase in seizure threshold current was observed after 7, 14 and 21 days of treatment. Conclusion: Fluoxetine exhibited anticonvulsant activity against ICES induced seizures.


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