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Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 333-339

Motilin receptor agonists as novel gastrointestinal prokinetic agents

Correspondence Address:
Salat Pinky

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Source of Support: None, Conflict of Interest: None

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Motilin is a naturally occurring gastrointestinal (GI) polypeptide which stimulates GI smooth muscle contractility through motilin receptors. Motilides are members of macrolide family which exhibit prokinetic activity by acting as motilin receptor agonists but lack antibacterial activity. The mechanism for smooth muscle contractile effect of motilin/motilides involve activation of voltage sensitive Ca2+ channels and release of Ca2+ from intracellular Ca2+ stores via G protein linked phospholipase C/inositol 1,4,5 trisphosphate pathway. None of the currently available drugs qualify as an ideal prokinetic agent due to variable efficacy and side effects. Motilides possess potent gastroprokinetic activity and do not produce side effects. They may be considered as drugs of choice for the treatment of various GI functional motor disorders like gastro-oesophageal reflux disease, gastroparesis, postoperative ileus, scleroderma and idiopathic pseudo-obstruction.


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