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Year : 1999  |  Volume : 31  |  Issue : 4  |  Page : 315-318

Expression of inducible and neuronal nitric oxide synthase in 20-methyl cholanthrene (20-MCA) induced fibrosarcoma



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S Sengupta


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Objective: Studies have shown that expression and localisation of nitric oxide synthase (NOS) depends on the type and differentiation status of different types of tumours. The present study was conducted to evaluate the expression of NOS in carcinogen induced tumour. Method: Swiss albino mice were injected with 20-methyl cholanthrene. Seventy six percent of the animals were positive for fibrosarcoma at the end of 100 days following exposure. The tumours were excised when they reached a predetermined size and immunostained for inducible and neuronal NOS. The staining was graded on an increasing intensity scale. Results: The tumour sections stained very strongly for iNOS as compared to controls (identical sections from tumour negative mice). Weak staining was detected for nNOS in the tumour sections unlike controls. Conclusions: NO may be involved in carcinogen induced fibrosarcoma as seen from the expression of its synthesising enzymes.






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