| RESEARCH PAPER
|Year : 1999 | Volume
| Issue : 4 | Page : 311-314
Effect of phenobarbitone, carbamazepine and sodium valproate on the elimination kinetics of acetaminophen
MM Shah, R Balaraman
Objective: To study the effects of phenobarbitone, carbamazepine and sodium valproate treatments on the elimination kinetics of acetaminophen in rabbits.
Methods: In the control session, each rabbit was treated with an intravenous dose of acetaminophen (46.67 mg/kg, i.v.). Starting on the following day, rabbits in the three groups were treated with phenobarbitone (16.33 mg/kg/day; p.o.; 21 days), carbamazepine (56.00 mg/kg/day; p.o.; 10 days) and sodium valproate (65.00 mg/kg/day; p.o.; 7 days), respectively. Acetaminophen administration was repeated on the subsequent day. Blood samples were collected in each session, for the estimation of plasma acetaminophen levels.
Result: In the phenobarbitone treated group, clearance rate of acetaminophen was increased. It was not significantly changed in the both carbamazepine and sodium valproate treated groups.
Conclusion: Phenobarbitone induced the metabolism of acetaminophen in rabbits whereas carbamazepine and sodium valproate failed to do so.
M M Shah
Source of Support: None, Conflict of Interest: None