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Year : 1999  |  Volume : 31  |  Issue : 4  |  Page : 311-314

Effect of phenobarbitone, carbamazepine and sodium valproate on the elimination kinetics of acetaminophen

Correspondence Address:
M M Shah

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Source of Support: None, Conflict of Interest: None

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Objective: To study the effects of phenobarbitone, carbamazepine and sodium valproate treatments on the elimination kinetics of acetaminophen in rabbits. Methods: In the control session, each rabbit was treated with an intravenous dose of acetaminophen (46.67 mg/kg, i.v.). Starting on the following day, rabbits in the three groups were treated with phenobarbitone (16.33 mg/kg/day; p.o.; 21 days), carbamazepine (56.00 mg/kg/day; p.o.; 10 days) and sodium valproate (65.00 mg/kg/day; p.o.; 7 days), respectively. Acetaminophen administration was repeated on the subsequent day. Blood samples were collected in each session, for the estimation of plasma acetaminophen levels. Result: In the phenobarbitone treated group, clearance rate of acetaminophen was increased. It was not significantly changed in the both carbamazepine and sodium valproate treated groups. Conclusion: Phenobarbitone induced the metabolism of acetaminophen in rabbits whereas carbamazepine and sodium valproate failed to do so.


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