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Year : 1999  |  Volume : 31  |  Issue : 4  |  Page : 290-293

The influence of tricyclic antidepressants on resutured incision and dead space wound healing in albino rats

Correspondence Address:
S S Muppayyanavarmath

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Source of Support: None, Conflict of Interest: None

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Objectives: To investigate the influence of tricyclic antidepressants (TCAs) viz., desipramine (DMI), clomipramine (CLO) and amitriptyline (AMI) on resutured incision and dead space wound healing. Methods: Resutured incision and dead space wounds were induced in Wistar rats of either sex under light ether anaesthesia, taking aseptic precautions. Control animals received normal saline and other groups received DMI, CLO and AMI for a period of 10 days. On eleventh day after estimating breaking strength of resutured incision wounds (under anaesthesia) animals were sacrificed and granulomas were removed for estimating breaking strength, quantification of granulation tissue and their biochemical as well as histological studies in control and various treated groups. Results: Both DMI and CLO significantly increased the breaking strength of incision wound, dry weight and hydroxyproline content of granulation tissue when compared to control group. In AMI treated group there was no significant change in both the wound models employed. Conclusion: DMI and CLO may promote wound healing while AMI did not affect the healing.


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