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Year : 1999  |  Volume : 31  |  Issue : 4  |  Page : 275-278

Effect of therapeutics strategy established by N-acetyl cysteine and vitamin C on the activities of tumour marker enzymes in vitro

Correspondence Address:
A J Vanisree

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Source of Support: None, Conflict of Interest: None

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Objectives: To assess the therapeutic efficiency of N-acetylcysteine (NAC) and Vitamin C (VC) by estimating the activities of tumour marker enzymes in vitro. Methods: Human lung carcinoma cell line, NCI-H82, was maintained in RPMI-1640 medium. The cells were divided into three groups (group II, III and IV) and each monolayer was subjected to drug treatment with NAC, VC and NAC+VC respectively. The cells without any supplementation served as control (group I). After 48 hours supplementation with the drugs, the cells were harvested for the estimation of aldolase, (-GT, 5'-nucleotidase, adenosine deaminase, lactate dehydrogenase and creatine kinase. Results: The activities of aldolase, (-GT, 5'-nucleotidase, lactate dehydrogenase and creatine kinase were found to be altered but no change could be observed in the activity of adenosine deaminase. Conclusion: The enzymes studied were found to be affected by the action of N-acetylcysteine and vitamin C, and this effect of the drugs on enzymes might contribute to the drugs action against cancer cells.


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