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Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 242-243

Potentiation of antiulcer effect of famotidine by calcium channel antagonists-a pharmacodynamic or pharmacokinetic interaction

Correspondence Address:
M C Gupta

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Source of Support: None, Conflict of Interest: None

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Objective: To study the neuropsychobehavioural effects of traditional silver preparations: Raupya Bhasma, Kushta Nuqra and Chandi Warq. Methods: The preparations were subjected to a battery of 30 tests for general neuropsychopharmacological effects, cognitive functions, antidepressant, anxiolytic, neuroleptic and serenic activities, effects on growth, body weight, endurance and fatigue. Results: The test drugs (50 mg/kg, p.o.) caused significant reduction of haloperidol-induced catalepsy in rats. Incorporation in the diet of rat pups (1% w/w for 6 weeks) lead to significantly higher growth rate when compared to control animals. No appreciable effects were discernible on other parameters. Conclusion: Silver preparations used in Ayurveda and Unani-Tibb showed anticataleptic and growth promoting effects without gross or subtle toxicities, weight loss, sedation, motor deficit, aggression or ill effects on cognitive functions.

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