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Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 232-233

Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc., Vitex negundo Linn and Tinospora cordifolia (willid) Miers in albino rats

Correspondence Address:
Jana Utpalendu

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the anti-inflammatory effect of Zingiber officinale, Vitex negundo and Tinospora cordifolia on carrageenin induced hind paw oedema and cotton pellet granuloma in rats. Methods: Hind paw oedema was produced by subplanter injection of carrageenin and paw volume was measured plethysmometrically at '0' and '3' hours intervals after injection. Cotton pellet granuloma was produced by implantation of 50(1mg sterile cotton in each axilla under ether anaesthesia. The animals were treated with Zingiber officinale, Vitex negundo, Tinospora cordifolia and the standard drugs acetylsalicylic acid and phenylbutazone. Results: Zingiber officinale, Vitex negundo and Tinospora cordifolia produced significant anti-inflammatory effect in both acute and subacute models of inflammation. In acute inflammation, effect of Tinospora cordifolia was more than acetylsalicylic acid. In subacute inflammation, the results of these drugs were less than phenylbutazone. Conclusion: Zingiber officinale, Vitex negundo and Tinospora cordifolia possess anti-inflammatory effects in both acute and subacute inflammation.


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