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Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 229-231

Effect of gentamicin on specific immune response in rabbits

Correspondence Address:
H B Asha

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Source of Support: None, Conflict of Interest: None

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Objective: To study the effect of gentamicin on humoral and cell mediated immune system in rabbits. Methods: Rabbits were treated with gentamicin at 4 mg/kg and 8mg/kg body weight doses for 5 days along with single intramuscular injection of 0.5 ml of Brucella plain killed antigen and humoral and cellular immune responses were measured. Results: There was no significant variation in the humoral and cellular immune response between the antigen control and the groups given gentamicin along with antigen. Conclusion: Gentamicin at the two dose levels used for 5 days, in rabbits, did not affect the specific immune response.


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