| RESEARCH PAPER
|Year : 1999 | Volume
| Issue : 3 | Page : 195-199
Effect of dietary calcium, lisinopril and insulin on diabetic hypertensive animals
MM Shah, CD Upasani, R Bharatrajan, R Balaraman, SP Rathod
Objectives: To compare the effect of calcium enriched diet (2% CED, 8 weeks), lisinopril (5 mg/kg/day, p.o., 2 weeks) and insulin (1 U/kg/day, s.c., 2 weeks) on blood pressure and vascular reactivity of diabetic rats and diabetic hypertensive rats.
Methods: In the first set of experiments, blood pressure and vascular reactivity of diabetic rats (alloxan, 150 mg/kg, i.p., single dose) was compared with that of diabetic rats treated with CED, lisinopril and insulin. In the second set of experiments, blood pressure and vascular reactivity of diabetic hypertensive rats (unilateral nephrectomy followed by DOCA, 25 mg/kg/week, s.c., 5 weeks) was compared with that of diabetic hypertensive rats treated with CED, lisinopril and insulin.
Results: Administration of CED and lisinopril significantly reduced the blood pressure and vascular reactivity in diabetic as well as diabetic hypertensive rats whereas insulin reduced these significantly only in the diabetic rats.
Conclusion: CED and lisinopril exhibited significant antihypertensive effect in the diabetic hypertensive model.
M M Shah
Source of Support: None, Conflict of Interest: None