IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1022 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded134    
    Comments [Add]    

Recommend this journal


Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 187-189

Effect of calcium channel blockers on aluminium treated rat brain serine/threonine phosphoprotein phosphatase 2B

Correspondence Address:
Basu Srabanti

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To examine the effect of aluminium (Al) on different types of phosphatases in rat brain in the presence and absence of Ca 2+ channel blockers. Methods: Phosphoprotein phosphatase activities were measured in brains of male Sprague Dawley rats treated with aluminium chloride (AlCl3 ) , Ca2+ channel blockers per se and AlCl3 with Ca2+ channel blockers for 40 days using standard techniques. Results: Tyrosine phosphoprotein phosphatase (TPP) activity, activation of TPP by EDTA and activity of serine/threonine phosphoprotein phosphatase 2B (PP2B) were decreased by Al. Nifedipine treated rats regained the activities of TPP and PP2B and showed increased activity of serine/threonine phosphatase 2C (PP2C). Verapamil and diltiazem were ineffective in restoring the normal activities of the enzymes. Conclusion: The restoration of the activity of PP2B by nifedipine indicates that there may be a competition between Al and Ca and between Al and Ca2+ channel blocker nifedipine. Hence the Ca 2+ channel blocker nifedipine can be used to prevent Al 3+ toxicity.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow