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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 96-103

Antiretroviral drugs in HIV infection

Correspondence Address:
Vajpayee Madhu

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Source of Support: None, Conflict of Interest: None

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Antiretroviral drugs directed at various targets in the replication cycle of HIV are now in clinical use. The earliest drugs available were the nucleoside analogue reverse transcriptase (RT) inhibitors. Subsequently non-nucleoside RT inhibitors were also introduced into clinical use. The newly developed HIV protease inhibitors have shown excellent efficacy, leading to optimistic attempts at "virus eradication". The trend in HIV antiretroviral therapy has shifted in recent years from monotherapy to combination therapy with even 3 drugs used simultaneously, and from treatment late in disease to early in infection. These approaches are based on the replication characteristics of the virus. A large number of clinical trials have been carried out and are ongoing for the evaluation of the various antiretroviral drugs in different treatment regimens. This review presents information on the antiretroviral drugs currently available for clinical use against HIV, along with the rationale and evolution of the strategies of anti-HIV therapy.


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