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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 142-145

Involvement of K-ATP channel in inhibition of cholinergic component of single pulse-stimulated neurogenic response in rat urinary bladder

Correspondence Address:
A G Telang

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Source of Support: None, Conflict of Interest: None

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Objective: To examine the involvement of K ATP channels in inhibition of single pulse induced responses in rat detrusor muscle. Methods: The rat bladder strips were stimulated with square wave single pulse of 1ms duration at 80V. The effect of pinacidil and cromakalim on responses to single pulse stimulation either in absence or presence of glibenclamide was evaluated. Results: The single pulse stimulation of bladder strips elicited a biphasic neurogenic response having noncholinergic (fast) and cholinergic (slow) components. Pinacidil and cromakalim(10 -6 M) caused significant inhibition of the cholinergic component. Glibenclamide (10 -6 M) pretreatment prevented the inhibition of slow component. Conclusion: K ATP channels primarily involved in inhibition of cholinergic component of single pulse induced neurogenic response in rat urinary bladder.


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