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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 138-141

Investigations into the anti-diabetic activity of Azadirachta indica

Correspondence Address:
Bajaj Sonia

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate the anti-diabetic activity of Azadirachta Indica using IDDM and NIDDM animal models . Methods: Streptozotocin induced models of IDDM (65 mg/kg, iv) as well as NIDDM model (90 mg/kg, i.p in neonates) were given neem leaf extract (NLE, 1 g/kg, po) for 6 weeks and their anti-diabetic activity was assessed. Result: The treatment with insulin, aqueous NLE, aqueous NLE with insulin and insulin with aminoguanidine showed a fall in blood glucose levels of 80, 45.4, 38.02 and 77-65% whereas in NIDDM model, a fall of 53.95 and 60.50% were observed with glibenclamide and NLE. Conclusion: Aqueous extract of NLE has a good therapeutic potential as anti-hyperglycaemic agent in IDDM and NIDDM.


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