| RESEARCH PAPER |
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| Year : 1999 | Volume
: 31
| Issue : 2 | Page : 138-141 |
Investigations into the anti-diabetic activity of Azadirachta indica
Bajaj Sonia, BP Srinivasan
Correspondence Address:
Bajaj Sonia
 Source of Support: None, Conflict of Interest: None  | Check |
Objective: To investigate the anti-diabetic activity of Azadirachta Indica using IDDM and NIDDM animal models .
Methods: Streptozotocin induced models of IDDM (65 mg/kg, iv) as well as NIDDM model (90 mg/kg, i.p in neonates) were given neem leaf extract (NLE, 1 g/kg, po) for 6 weeks and their anti-diabetic activity was assessed.
Result: The treatment with insulin, aqueous NLE, aqueous NLE with insulin and insulin with aminoguanidine showed a fall in blood glucose levels of 80, 45.4, 38.02 and 77-65% whereas in NIDDM model, a fall of 53.95 and 60.50% were observed with glibenclamide and NLE.
Conclusion: Aqueous extract of NLE has a good therapeutic potential as anti-hyperglycaemic agent in IDDM and NIDDM.
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