IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 196 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2288    
    Printed113    
    Emailed0    
    PDF Downloaded594    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 133-137

Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation



Correspondence Address:
S K Mitra


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To evaluate the antiasthmatic and antianaphylactic activity of E-721B in various experimental models. Methods: The antiasthmatic and antianaphylactic activity of E-721B was studied on the active and passive anaphylaxis in rats, acetyl choline-induced bronchospasm in guinea pigs, anaphylactic shock-induced bronchospasm in guinea pigs and rats and on degranulation of mast cells by Compound 48/80. Results: Treatment with E-721B showed a dose dependent (at 50, 100, 250 and 500 mg/kg p.o.) beneficial effect on degranulation rate of actively and passively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum). E-721B treatment for 7 days resulted in significant protection against acetylcholine aerosol-induced bronchospasm in guinea pigs. E-721B treatment for 10 and 14 days, in guinea pigs and rats respectively, offered marked protection against anaphylactic shock-induced bronchospasm. E 721B treatment also protected the mast cell disruption induced by Compound 48/80. Conclusion: Antiasthmatic and antianaphylactic activity of E-721B may be possibly due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow