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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 124-127

The effect of panax ginseng and diazepam on norepinephrine levels of whole brain and hypothalamus during stress

Correspondence Address:
D Bhattacharyya

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Source of Support: None, Conflict of Interest: None

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Objective: To see the effect of anti-stress agents like Panax ginseng and diazepam on stress-induced elevation of norepinephrine (NE) in brain and hypothalamus of rats. Methods: NE was estimated in brain and hypothalamus of rats by spectrophotofluorimetry. Plasma corticosterone was measured by fluorimetry. Results: Panax ginseng and diazepam both per se did not modify NE levels of brain and hypothalamus in unstressed rats. But both the drugs attenuated stress-induced elevation of NE of brain and hypothalamus and simultaneously attenuated stress-induced elevation of plasma corticosterone. Conclusion: Anti-stress effect of Panax ginseng and diazepam seems to be mediated through attenuation of levels of NE in brain and hypothalamus.


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