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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 116-119

A study on the characteristics of Ca2+ channels in vas deferens isolated from cyclophosphamide treated rats

Correspondence Address:
Reddy A Gopala

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the functional characteristics of ca2+ channels in rat vas deferens following cyclophosphamide treatment. Methods: The study was conducted on vas deferens isolated from cyclophosphamide-treated (40 mg/kg s.c., once on alternate day for 5 times) albino rats. The following parameters were assessed: IC50 values of verapamil against 1 m mol BaCl 2 -induced rhythmic contractions, maximum absolute tension (g) generated by norepinephrine (NE) in the presence of verapamil 10-6 mol and EC 50 value of NE in inducing contractile responses in the presence of verapamil 10-6 mol. Results: The mean IC50 value of verapamil against BaCl2 -induced rhythmic contractions was significantly decreased, the maximum absolute tension generated by NE did not change significantly and the EC50 value of NE in the presence of verapamil was significantly increased in the cyclophosphamide-treated group as compared to the control. Conclusion: The study revealed decreased functional activity of Ca2+ channels of rat vas deferens following cyclophosphamide treatment.


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