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Year : 1999  |  Volume : 31  |  Issue : 1  |  Page : 33-35

Hypotensive activity of some new 6-(alkylamino-hydroxy propoxy) benzothiadiazines and substituted benzothiadiazines

Correspondence Address:
Ahmed Bahar

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Source of Support: None, Conflict of Interest: None

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Objective: To synthesize and study the hypotensive and (-blocking activity of some new 6-(alkylamino hydroxy propoxy) benzothiadiazines. Methods: The hypotensive activity was studied in normotensive albino rats at a single dose of drug (1 mg/kg body wt.) and compared wiht that of same dose of propranolol. The (-blocking effect was assessed as the percentage blockade of the effect of adrenaline (5(g) by the drugs (50(g) on Frog's isolated heart. Results: Administration of the synthesized drugs showed significant reduction in blood pressure comparable to that of propranolol at 1 mg/kg body weight dose level. Some of the derivatives (50(g) completely blocked the adrenaline (5(g) induced chronotropic effect on frog's isolated heart. Conclusion: Our experiment suggests that the compounds synthesized have significant (-blocking and hypotensive activity and may be recommended for further investigation.


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