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Year : 1999  |  Volume : 31  |  Issue : 1  |  Page : 23-28

Vascular responses in streptozotocin-induced diabetic monkey aortic strips

Correspondence Address:
S Savithiri

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Source of Support: None, Conflict of Interest: None

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Objective: To study the vascular responses in streptozotocin-induced diabetic monkeys. Methods: The monkeys were anaesthetized and a section of thoracic aorta was removed and cut into transverse strips. Vessels were suspended in a 10 ml organ bath containing Hank's physiological solution oxygenated with 100% oxygen. The tissues were equilibrated for 90 minutes under a resting tension of 3 g. Isometric tensions were recorded with a force displacement transducer and recorded on a student physiograph. After equilibration period, the relaxant and contractile responses were observed in control and diabetic monkey aortic strips. Results: The percent relaxation to acetylcholine was decreased in diabetic monkey aortic strips, whereas the percent relaxant response to sodium nitroprusside did not differ significantly. This indicates impaired endothelium dependent relaxation in diabetic monkey aortic strips. In addition, the contractility to phenylephrine was increased in monkey aortic strips but not to potassium chloride. There was structural and functional impairment observed in diabetic monkey aortic tissues. Conclusion: The monkey aortic strips from streptozotocin-induced diabetic monkeys showed structural and functional impairment.


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