| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 5 | Page : 329-333
Proconvulsant effect of buspirone and its modulation by a2-adrenoceptor agonist in mice
Vohora Divya, KK Pillai
Objectives: To study (a) the effect of buspirone on chemically-induced seizures in mice and (b) the possible receptor mechanisms involved.
Methods: Picrotoxin 8 mg/kg ip was used for inducing seizures in mice. The onset and duration of convulsions and recovery/ death were observed. Animals were also observed for different stages of convulsions and a severity score was assigned to them.
Results: Buspirone (20 mg/kg po) potentiated PTX-induced convulsions and reversed the anticonvulsant effect of diazepam. Clonidine pretreatment protected against the pro-convulsive effects of buspirone. Mianserin exhibited an effect similar to that of buspirone.
Conclusion: Buspirone exhibited pro-convulsive action on seizures induced with PTX in mice. The study suggests a role of central ((-adrenoceptor in such effects.
Source of Support: None, Conflict of Interest: None