| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 5 | Page : 326-328
Potentiation of antiepileptic activity of phenytoin by calcium channel blockers against maximal electroshock seizure in mice
RN Chattopadhyay, S Chaudhuri, RK Roy, S Mandal, HL Lahiri, SK Maitra
Objectives: To study the antiepileptic effect of verapamil, nifedipine and diltiazem against MES in mice.
Methods: MES was induced in mice by a Techno Electroconvulsometer (50m Amp, 0.1 sec. duration). The abolition or reduction of duration of tonic extension was considered as the index for antiepileptic effect. The animals were treated with calcium channel blockers alone and in combination with phenytoin sodium.
Results: Verapamil, nifedipine and diltiazem produced no significant antiepileptic effect alone. Verapamil and nifedipine potentiated the antiepileptic effect of phenytoin sodium but diltiazem exerted no such potentiating effect.
Conclusion: Dose of phenytoin sodium can be reduced in epileptic patients receiving verapamil or nifedipine for some other clinical conditions.
R N Chattopadhyay
Source of Support: None, Conflict of Interest: None