| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 5 | Page : 306-310
Anticonvulsant effect of nalbuphine on maximal electroshock seizure in mice
Manocha Anshu, KK Sharma, PK Mediratta
Objective :The study was designed to investigate the pro-or anticonvulsant action of natbuphine using maximal electroshock (MES) test. An attempt was also made to determine the possible opioid receptor mechanism involved.
Method : MES seizures were induced in mice via transauricular electrodes (60mA, 0.2 sec). Seizure severity was assessed by the duration of hindlimb extensor phase.
Results : lntraperitoneal administration of nalbuphine resulted in a dose-dependent inhibition of the hindlimb extensor phase during the MES. This anticonvulsant effect was antagonized by naloxone, MR2266 and naltrindole.
Conclusion :The results suggest that the anti-MES effect of nalbuphine is evoked by stimulation of mu, kappa and delta receptors, since the effect was attenuated by respective receptor antagonists.
Source of Support: None, Conflict of Interest: None