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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 254-256

Effect of trikatu (PIPERINE) on the pharmacokinetic profile of isoniazid in rabbits



Correspondence Address:
R S Karan


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Source of Support: None, Conflict of Interest: None


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Objective: To see the effect of Trikatu (piperine) on the bioavailability and pharmacokinetics of isoniazid in rabbits. Methods: In a crossover study, ten rabbits were administered either single dose (orally) of isoniazid (14 mg/kg) alone or in combination with Trikatu [piperine (10mg/kg)] Blood samples were collected at 0,0.5,1 ,1.5,2, 4,6,9 and 12 hours after drug administration and assayed for isoniazid by fluorimetric technique. A washout period of 7 days was allowed between the two treatments. Results : Coadministratfon of Trikatu (piperine) significantly reduced the Cmax (5.48 ˝ 0.75 'g/ml vs 8.42 ˝ 0.85 'g/ml; P < 0.05] and AUCo-( [15.04 ˝ 3.64 'g/ml. hr vs 24.76(4.03 'g/ml. hr; P< 0.05] of isoniazid. Condusion: Trikatu (piperine) reduces the bioavailability of isoniazid in rabbits.






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