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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 249-253

Effect of pethidine on spermatogenesis in albino rats



Correspondence Address:
Patil Srinivasreddy


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0bjectives:To find the effect of pethidine on spermatogenesis in albino rats. Methods: Pethidine at the dose level of 5.0mg and 7.5 mg/kg. body wt in 0.2 ml saline was administered intraperitoneally to male albino rats for 30 days, suitable saline treated control group was maintained. Gonadosomatic index, spermatogenic elements, cauda epididymal sperm count, accessory sex organ weights were considered to study the effect of pethidine. Results: Pethidine administred at the dose level of 5.0 and 7.5mg/kg body wt has decreased the testis weight significantly (1101.51 ˝ 56.76 mg/100 gm and 956.28 ˝ 36.24 mg/1 00 gm ) when compared to the saline treated controls (1237.19 ˝ 48.68 mg/100 gm). Simillarly the diameter of testis and seminiferous tubules is also reduced in pethidine treated albino rats (3.21 ˝ 0.16 mm, 3.05 ˝ 0.21 mm and 156.40 ˝ 9.4 pm, 138.24 ˝ 11.7 'm respectively from 3.72 ˝ 0.12mm and 192.78 ˝ 10.4'm) while the total cholesterol content of the testis increased (8.16 ˝ 1.26 mg/gm and 10.21 ˝ 2.05 mg/gm from 5.40 ˝ 0.69 mg/gm). Pethidine has inhibited the process of spermatogenesis and reduced the caudaepididymal sperm count, accessory sex organ weights, and the protein and glycogen contents of the testis. Conclusion:Pethidine showed a dose dependent Inhibition on the gravimetrfc, micrometric and spermatogenic indices.






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