| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 4 | Page : 245-248
Anti-inflammatory effects of fluticasone, a topically active synthetic corticosteroid and its combination formulations in histamine induced cutaneous responses in healthy human volunteers
SR Shahani, HR Jerajani, K Sharma, ND Cooverji
Objective: To evaluate and compare the biorelease of fluticasone, a topically active synthetic corticosteroid alone with placebo (ointment base) and its combination with antifungal (miconazole. clotrimazole) and/or antibacterial agent (neomycin) based on attenuation of histamine induced wheal and flare reaction, and their intensity.
Methods: The study was a randomized, open controlled and comparative trial, carried out in 24 healthy adult volunteers. Effect of different formulations on wheal and flare was observed after injecting histamine intradermally
Results: Fluticasone alone and in different formulations were equally effective in reducing histamine induced wheal and flare, while their ointment bases did not alter the histamine response.
Conclusion: Antibacterial (neomycin) and/or antifungal (miconazole, clotrimazole) agents did not alter the biorelease of fluticasone.
S R Shahani
Source of Support: None, Conflict of Interest: None