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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 245-248

Anti-inflammatory effects of fluticasone, a topically active synthetic corticosteroid and its combination formulations in histamine induced cutaneous responses in healthy human volunteers



Correspondence Address:
S R Shahani


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Source of Support: None, Conflict of Interest: None


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Objective: To evaluate and compare the biorelease of fluticasone, a topically active synthetic corticosteroid alone with placebo (ointment base) and its combination with antifungal (miconazole. clotrimazole) and/or antibacterial agent (neomycin) based on attenuation of histamine induced wheal and flare reaction, and their intensity. Methods: The study was a randomized, open controlled and comparative trial, carried out in 24 healthy adult volunteers. Effect of different formulations on wheal and flare was observed after injecting histamine intradermally Results: Fluticasone alone and in different formulations were equally effective in reducing histamine induced wheal and flare, while their ointment bases did not alter the histamine response. Conclusion: Antibacterial (neomycin) and/or antifungal (miconazole, clotrimazole) agents did not alter the biorelease of fluticasone.






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