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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 239-244

Sub-acute toxicity study of a polyherbal drug (prostina®) in rats



Correspondence Address:
N R Biswas


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Objectives: Sub-acute toxicity study of a polyherbal drug (Prostlna) was carried out in albino rats to assess its effects on morphological, gross behaviour, body weight changes as well as to find out histopathological, biochemical and hematological changes. Methods: Eighty albino rats were divided equally into four groups.They were fed with distilled water, and the test drug (90, 300 and 450 mg/kg) daily for 90 days. Cage-side observation, changes in morphology, behaviour and body weight were weekly noted. At the end of the exposure period biochemical, hematological and pathological changes (macroscopic and microscopic) were examined. Results: The sub-acute toxicity studies on the drug reflected innocuous nature of this pdyherbal preparation on hepatic, renal and haemopoietlc system even on 15 times higher than recommended dose level (450 mg/kg body weight) on daily administration for 90 days. This is also confirmed by detailed histopathological studies. There was no change in rectal temperature and no mortality was seen. Conclusions: The polyherbal drug (Prostina) is devoid of toxic effects in rats upto the dose of 450 mg/kg which is 15 times higher than the recommended dose.






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