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Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 227-232

Effects of GABA synthesis blockade in the analgesia induced by the physical and psychological stressors

Correspondence Address:
R Chandramouli

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Source of Support: None, Conflict of Interest: None

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Objectives: To investigate the role of GABA in the analgesia produced by the physical and psychological stressors in rats. Methods: Rats were exposed to physical stress (cold water swim stress) and psychological stress (fear) with and without the pretreatment of GABA synthesis inhibitor thiosemicarbazide (5 mg/kg ) in separate groups.Tail flick test was done using analgesiometer to assess the antinociceptive response. The analgesic response was measured as tail flick latency, recorded at the basal time, 10, 20 and 30 minutes duration of time intervals. The data obtained was compared with the control and between the groups. Results: Antinociceptive response was significant, as revealed, at the basal time measurement of tail flick latency, in the drug treated and drug free rats, exposed to the physical stress. Similar significance was also present in the drug free animals exposed to the psychological stress, while the group, which received GABA synthesis inhibitor and exposed to the psychological stress, did not show any significant antinociceptive response. Conclusion: In psychological stress induced analgesia GABA mechanism may be involved but it may not be involved in the analgesia produced by the physical stress.


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