| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 3 | Page : 163-168
lmmunopotentiating and immunoprophylactic activities of lmmue 21, a polyherbal product
De Pallabi, SC Dasgupta, A Gomes
Objective: To evaluate the immunopotentiating and immunoprophylactic effects of Immue-21 (l-21) a polyherbal Ayurvedic product.
Methods: Effect of l-21 (50 mg/kg, p.o), on morphometric and functional changes of mouse peritoneal macrophage was evaluated. Its effect on chemotaxis assay for leucocytes and on heamatological parameters were also studied. Adjuvant effect of l-21 was studied in rabbits. lmmunopotenttating effect of l-21 was studied against UV rays,cyclophosphamide and cyclosporine induced immunosuppression in mice and rats. lmmunoprophylactic effect of l-21 was studied in E.coli induced peritonitis in mice.
Results: l-21 exhibited a significant increase in both morphometric and functional changes of macrophage in mice. It also significantly increased in vitro chemotaxis of leucocytes and in vivo total WBC and RBC counts in albino mice. l-21 significantly potentiated humoral immunity in rabbits and showed significant protection against UV rays, cyclophosphamide and cyclosporine A induced immunosuppression. l-21 provided 50% protection against E. coli induced abdominal peritonitis in albino mice.
Conclusion: l-21 may have immunopotentiattng and immunoprophylactfc activity.
D e Pallabi
Source of Support: None, Conflict of Interest: None