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Year : 1998  |  Volume : 30  |  Issue : 3  |  Page : 152-162

Role of S-Allyl cysteine sulphoxide in antagonizing deleterious metabolic effects of monosodium glutamate in rats on atherogenic diet

Correspondence Address:
K N Bopanna

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Source of Support: None, Conflict of Interest: None

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0bjective:To study the effect of S-allyl cysteine sulphoxide (SACS) in antagonising deleterious metabolic effects of monosodium glutamate in rats on atherogenic diet. Methods: Rats on atherogenic diet with monosodium glutamate at two doses received SACS for thirty days. At the end of thirty days, blood pressure, heart rate, serum lipid levels and activities of some serum, liver, heart and intestinal enzymes were assessed. Results: SACS significantly decreased the concentration of serum lipids except HDL cholesterol and enzyme activities in serum, liver, heart and intestine in rats treated with MSG at both doses. There was no significant effect of SACS on phosphatases in rats treated with MSG (1 g/kg). SACS did not have any significant effect on blood pressure and heart rate. SACS significantly decreased pentobarbitone induced sleeping time in rats on MSG with atherogenic diet. Conclusions: Our data suggests that SACS significantly antagonises the metabolic aberrations caused by MSG in rats on atherogenic diet.


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