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Year : 1998  |  Volume : 30  |  Issue : 2  |  Page : 89-93

Changes in glucose metabolising enzymes in adjuvant arthritis and its treatment with a Siddha drug: Serankottai Nei

Correspondence Address:
T Vijayalakshmi

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Source of Support: None, Conflict of Interest: None

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Objectives: To evaluate the effect of Serankottai Nei, a Siddha preparation of Semecarpus anacardium nut extract on adjuvant arthritis associated carbohydrates metabolic changes in albino rats. Methods: The drug was administered at a dose level of 150 mg/kg body weight for 14 days to arthritic animals after 14 days from the day of adjuvant injuction. At the end of the experimental period the glucose metabolizing enzymes (glycolytic and gluconeogenic) activities were studied in control, arthritis induced and drug treated groups. In addition transaminases activities and blood glucose levels were also analysed. Results: Significantly decreased activity of glycolytic enzymes with concomitant increase in the activities of gluconeogenic enzymes and blood glucose levels developed during arthritic condition were reverted back to near normal in drug treated animals. Conclusion: These observations suggest that the carbohydrate metabolism was significantly affected during arthritic condition and the Siddha drug,Serankottai Nei, may normalise it.


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