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Year : 1998  |  Volume : 30  |  Issue : 2  |  Page : 68-72

Toad (Bufo Melanostictus, Schneider) skin extract induced haematological and biochemical changes in rodents

Correspondence Address:
Das Manika

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Source of Support: None, Conflict of Interest: None

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0bjective:To examine the haematological and biological changes induced by the toad skin extract (TSE) of the common Indian toad (Bufo melanostictus) in rodents. Methods:TSE was injected (SC) in male albino mice and rat (normal and splenectomized) and haemoglobin, haematocrit, RBC and WBC counts were done at different time intervals. Serum glucose, cholesterol, HDL-cholesterol, triglycerides, urea creatinine, iron, total iron binding capacity (TIBC), transaminase and phosphatase levels were also measured on TSE injected male albino rats. Results: TSE significantly decreased haemoglobin, haematocrit and total RBC count of male albino mice. However, it significantly increased total WBC, lymphocyte and monocyte count. In splenectomized rat, TSE showed no change on haemoglobin, haematocrit and total RBC count but increased total WBC and lymphocyte count. TSE also produced significant fall of serum glucose, cholesterol, triglyceride, urea and transminase levels and increased serum iron and TIBC level in male albino rats. Conclusion:TSE induced changes on haematological and biochemical parameters in rodents, indicated the toxic nature of TSE.This toxicity of TSE probably provides first line of defence in toad against predators.


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