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Year : 1998  |  Volume : 30  |  Issue : 1  |  Page : 51-53

Evaluation of sensitivity of Plasmodium falciparum to Morinda lucida leaf extract sample using rabbit in vitro microtest technique

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S O Awe

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Source of Support: None, Conflict of Interest: None

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Objective: To evaluate the antimalarial activity of Morinda Lucida leaf extract, using a rabbit in vitro model. Methods: The petroleum ether extract and fractions of the leaf samples of Morinda lucida were evaluated for antimalarial effects against Plasmodium falciparum using the rabbit in vitro technique. The sera collected from rabbits administered with the extract, fractions, chloroquine (Standard) and normal saline. These were used to evaluate their activity in inhibiting growth of the parasites in vitro. Results: The petroleum ether extract, chloroquine and fractions A and C at the employed doses inhibited the P. falciparum growth. Conclusion: Petroleum ether extract and some fractions of M. lucida inhibited the maturation of drug sensitive strain of P falciparum in-vitro.


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