| RESEARCH PAPER |
|
| Year : 1998 | Volume
: 30
| Issue : 1 | Page : 47-50 |
Pharmacokinetics and renal excretion of gentamicin in goats after intravenous administration
RP Uppal, SP Verma, SK Garg
Correspondence Address:
R P Uppal
 Source of Support: None, Conflict of Interest: None  | Check |
Objective: To determine the disposition kinetics and urinary excretion of gentamicin following a single intravenous dose (10 mg/kg) and to workout the suitable dosage regimen for the goats.
Methods: The studies were conducted on five male goats. Blood samples were collected at different time intervals following a single intravenous dose of gentamicin (10 mgkg) and plasma concentrations of drugs were determined using the radioimmunoassay kits. The pharmacokinetics parameters were calculated by using the curve stripping and non-linear least square regression computer programmes and the dosage regimen calculated. Seventy two hours cumulative urinary excretion of gentamicin was also determined following drug administration.
Results: The plasma disposition of the drug could best be described by two compartment open model. The distribution and elimination half life values of gentamicin were found to be 0.05 and 2.05 h, respectively. The mean ñ SEM values of apparent volume of distribution at steady state (Vdss) and the total body clearance (CIB) were calculated to be 0.23 ñ 0.04 L/kg and 1.37 ml/kg.min, respectively. The cumulative urinary excretion data revealed that urinary excretion during the first 24 h following drug administration was fast, as 67.7 ñ 0.44 per cent of the total administered drug was excreted in the urine.
Conclusion: To maintain the plasma concentrations of gentamicin within the safe therapeutic range, a rational dosage regimen for goats would be 1.8 and 1.5 mg/kg as the loading, and the maintenance doses, respectively, to be repeated at 6 hourly interval by intravenous route
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