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Year : 1998  |  Volume : 30  |  Issue : 1  |  Page : 25-29

Calcium dependency of the positive inotropic effects of phosphodiesterase inhibitors on the amphibian and mammalian myocardium

Correspondence Address:
A R Juvekar

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Source of Support: None, Conflict of Interest: None

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Objective: To study the relationship of changing Ca2+levels, to the inotropic responses of amphibian and mammalian myocardium, to phosphodiesterase (PDE) Ill inhibitors, milrinone and trequinsin hydrochloride (HL725). Methods: The inotropic effects of milrinone and HL725 were investigated, on the isolated perfused frog heart and the isolated electrically - paced guinea pig left atrium at different perfusate calcium levels. Results: HL725 and milrinone produced a dose-dependent positive inotropy effect. The mammalian myocardium exhibited greater magnitude of positive inotropic response as compared to the isolated frog heart. Conclusion: The responses to HL725 and milrinone are species specific; due to the inherent ultrastructural variations and the resultant changed intracellular Ca2+ mileu.


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