IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1160 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded151    
    Comments [Add]    

Recommend this journal


Year : 1998  |  Volume : 30  |  Issue : 1  |  Page : 21-24

Beneficial effects of combined administration of thiamine, methionine or zinc with few chelating agents in preventing acute cadmium toxicity in mice

Correspondence Address:
Gubrelay Udita

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: The efficacy of thiamine, methionine or zinc and few chelators either individually or in combination, to prevent acute cadmium toxicity in mice, was investigated. Methods: Mice were administered intraperitoneally (i.p.) a single lethal dose of cadmium and within few minutes were treated i.p. with either one of the chelators, thiamine, methionine or zinc either individually or in combination. Mortality was observed for next 3 days. In another set of experiment, mice were administered an acute dose of cadmium and were again treated with the above stated chemicals either individually or in combination. Distribution of cadmium in blood, liver and kidneys was determined after 48 hours. Results: Combined administration of zinc and sodium 2,3- dimercaptopropane 1 -sulfonate (DMPS) was more effective than any other treatment in preventing lethal effects of cadmium and accumulation of cadmium in blood and liver. Conclusion: Thiol chelators when administered in combination with zinc or methionine were more effective than Ca trisodium diethylenetriamine pentaacetic acid (CaNa3DTPA) in preventing appearance of toxic signs of acute cadmium toxicity.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow