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Year : 1997  |  Volume : 29  |  Issue : 6  |  Page : 426-428

Hepatoprotective activity of ethyl acetate extract of Acacia catechu

Correspondence Address:
P Jayasekhar

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate the hepatoprotective activity of ethyl acetate extract of Acacia Catechu, katha. Methods: The acute liver damage in albino rats was induced by a single subcutaneous administration of 4 ml/kg dose of 50% v/v of carbon tetrachloride in olive oil and the chronic liver damage by subcutaneous injection of 50% v/v carbon tetrachloride in olive oil at the dose of 2 ml/kg twice a week for 14 days. The hepatoprotective activity was monitored biochemically by estimating serum hansaminase, serum alkaline phosphatase and serum bilirubin in both the cases after intraperitoneal injection of ethylacetate extract of "katha" (250 mg/kg). The histopathological changes of liver samples were compared with that of control. Results: Ethyl acetate extract of "katha" inhibited carbon tetrachloride induced liver toxicity in albino rats at 250 mg/kg, b.w. as assessed by the biochemical and histopathological values. Conclusion: Ethyl acetate extract of "katha" exhibited significant hepatoprotective activity.


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