IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 8133 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded139    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 6  |  Page : 416-419

Modulation of brewer’s yeast-induced peripheral inflammation and nociception in rats by centrally administered prostaglandins and their inhibitors

Correspondence Address:
S K Hore

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To study the effect of centrally administered prostaglandins and cyclooxygenase inhibitors on Brewer's yeast-induced peripheral inflammation and nociception. Methods: Intracerebroventricular (ICV) cannulation was performed in rats. Arachidonic acid, PGE2 PGF2( paracetamol. aspirin and indomethacin were administered centrally, before acute inflammation was Induced by Brewer's yeast. The hind paw oedema volume and pain threshold were measured by plethysmometer and analgesiometer, respectively. Results: PGF2( paracetamol, aspirin and indomethacin significantly suppressed the paw oedema volume at various periods of inflammatory process. Arachidonic acid and PGE2 reduced the pain threshold while, paracetamol and aspirin significantly augmented the pain threshold. Conclusion: Centrally administered PGF2( effect on Brewer's yeast-induced acute inflammation and pain, providing evidence of involvement of 29 exerts anti-inflammatory while, PGE2 exerts pronociceptive CNS in modulation of peripheral inflammation and pain.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow