IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 7875 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded122    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 6  |  Page : 405-410

Molecular genetic markers predict development of drug-induced leukemias in patients undergoing cytotoxic therapy

Correspondence Address:
Kumaravel Bharathy

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To demonstrate the usefulness of fluorescence in situ hybridization(FISH) directed against monosomy 7 and 5q-, in early detection of therapy related acute myeloid leukemia (t-AML) in patients receiving cytotoxic chemotherapy. Methods: This is a retrospective study of five patients who developed t-AML/t-MDS after cytotoxic chemotherapy for primary malignant disorders. These patients underwent periodic cytogenetic work-up and the remaining samples were available for FISH analysis. Clinical and cytogenetic data concerning these patients were retrieved from the records of the Clinical Pathology Department. Sequential interphase FISH analysis with D7Z1 and 5q31.1 probe was performed as per standard protocols to detect the exact time of origin of these abnormalities. Results: FISH detected monosomy 7 and 5q-atleast 12-36 months before the onset of clinical manifestations in these patients. Conclusion: Molecular cytogenetic techniques can be of good use to clinical pharmacologists in early detection of t-AML in patients undergoing cytotoxic chemotherapy.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow