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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 350-358

The effect of herbal products on learning disturbance in senescence accelerated mouse

Correspondence Address:
Kishikawa Masao

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Source of Support: None, Conflict of Interest: None

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The preventive effect of the Japanese herbal medicine "Boui-Jiou-Tou (BJT)" on senility using Senescence Accelerated Mouse (SAMP 1 TA/Ngs), which is considered to be useful models of human ageing in some respects. The investigation of the effects of herbal medicine on the behaviour, learning ability, longevity and histological changes in this animal model may be important for basic studies on ageing in humans. Pellet feed containing 0.052% BJT was given to the treated group, consisting of 25 mice, ad libitum from the age of six weeks, for twenty-four weeks. Learning ability was assessed, and spontaneous motor activity was measured. A histological examination was carried out. The longevity of mice was also assessed. In the passive avoidance task, the period until acquisition of standard achievement rate was 3 days shorter in the treated group than in the control group. The mean number and density of dendritic spines were higher in the treated group than in the control group. With regard to life span, median survival time tended to be longer in the treated group (54 weeks) than in the control group (41 weeks). The results of this study suggest that BJT indeed exerts some valuable effect in the prevention of learning disturbance and senility.


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