| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 5 | Page : 322-324
Sub-acute toxicity studies on pendimethalin in rats
Shah MA Ayub, SK Garg, KM Garg
Objective: To investigate certain haematological and biochemical changes following 90 days administration of pendimethalin in rats.
Methods: Eighteen female rats were randomly divided into three groups. While one group served as control,the remaining two were administered pendimethalin at the dose rate of 24 and 48 mg/kg/day, orally once daily for 90 days. On day 46 and 91. all the animals were anaesthetized and blood samples were collected to study some haematological and biochemical profiles. Also, three rats from each group were sacrificed on day 91 to record the relative organ weights.
Results: Administration of pendimethalin (24 or 48 mgikg) did not produce any apparent signs of toxicity or mortality. However, it caused marginal reduction in haemoglobin (Hb), total erythrocyte count (TEC), significant (P<0.05) elevation in plasma cholesterol level and relative weights of liver and adrenals at higher dose. Pendimethalin did not cause any appreciable changes in total leucocyte count (TLC) and absolute lymphocyte count (ALC), plasma proteins, glucose and blood urea nitrogen (BUN) concentrations; and,alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities.
Conclusion: Administration of pendimethalin for 90 days exerts mild haemotoxic effect and probably interferes with lipid metabolism.
Shah MA Ayub
Source of Support: None, Conflict of Interest: None