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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 318-321

The effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress

Correspondence Address:
T K Sur

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Source of Support: None, Conflict of Interest: None

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Objective: To see the efect of anti-stress agents like Panax ginseng and diazepam on stress-induced elevation of 5-hydroxytryptamine (5-HT) in brain and hypothalamus of rats. Methods: 5-HT was estimated in brain and hypothalamus of rats by spectrophotofluorometry with simultaneous fluorimetric estimation of corticosterone as an index of activation of hypothalamo-hypophyseal- adrenal axis. Results: Panax ginseng and diazepam both per se did not modify brain and hypothalamic 5-HT in unstressed rats. But both of them attenuated stress-induced elevation of brin and hypothalamic 5-HT. Conclusion: Mediation of 5-HT in anti-stress effect of Panax ginseng and diazepam can not be conjectured, as they may have a non specific anti-stress effect.


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