| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 5 | Page : 318-321
The effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress
TK Sur, D Bhattacharyya
Objective: To see the efect of anti-stress agents like Panax ginseng and diazepam on stress-induced elevation of 5-hydroxytryptamine (5-HT) in brain and hypothalamus of rats.
Methods: 5-HT was estimated in brain and hypothalamus of rats by spectrophotofluorometry with simultaneous fluorimetric estimation of corticosterone as an index of activation of hypothalamo-hypophyseal- adrenal axis.
Results: Panax ginseng and diazepam both per se did not modify brain and hypothalamic 5-HT in unstressed rats. But both of them attenuated stress-induced elevation of brin and hypothalamic 5-HT.
Conclusion: Mediation of 5-HT in anti-stress effect of Panax ginseng and diazepam can not be conjectured, as they may have a non specific anti-stress effect.
T K Sur
Source of Support: None, Conflict of Interest: None