IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1008 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded107    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 310-313

Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits

Correspondence Address:
D Sharma

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To investigate the effect of metoprolol (cardioselective beta blocker), prazosin (alpha blocker) alone and in combination on reperfusion induced arrhythmias in intact rabbit hearts. Methods: Newzealand white rabbits of either sex weighing 1.5 to 2 kg were used. The coronary artery was ligated for 30 minutes and then reperfusion was carried out for 60 minutes. Metoprolol alone (0.5 mg, 0.75 mg and 1mg/kg B.wt.), prazosin alone (0.25 mg, 0.5 mg and 1mg/kg B.wt.) and combination of lowest dose of metoprolol (0.5 mg/kg) and prazosin (0.25 mgkg) was administered intravenously at the time of reperfusion in different groups of animals. Electrocardiogram was monitored every 5 minutes using limb lead II throughout the experiment. Incidence and severity of arrhythmias were analysed from ECG recordings. Results: Metoprolol in all doses produced slight bradycardia and percent protection against arrhythmias was 0 to 16.6% with different doses.Percent protection produced by prazosin was 33.3 to 66.6%. When metoprolol (lowest dose) was used in combination with prazosin (lowest dose) there was no change in heart rate and percent protection against arrhythmias was 83.3%. Conclusion: Combination of a cardioselective beta blocker (metoprolol) and an alpha blocker (prazosin) has produced potentiation of effect in protecting the heart against reperfusion induced arrhythmias in intact rabbit heart.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow