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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 306-309

Biochemical modes of action of Gmelina asiatica in inflammation

Correspondence Address:
Ismail T Syed

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Source of Support: None, Conflict of Interest: None

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Objective: To study the anti-inflammatory effect of G. asiatica root in male albino rats. Methods: Carrageenan-induced rat paw oedema (acute inflammation) and cotton pellet granuloma (chronic inflammation) methods have been used. Results: G. asiatica root powder was effective in reducing the oedema during the various phases of acute inflammation. In chronic phase the weight of cotton pellet granuloma was also reduced by G. asiatica treatment. G. asiatica also reduced the lipid peroxide content of granuloma exudate and liver, (-glutamyl transpeptidase in the granuloma. Serum albumin in granuloma was normalised. G. asiatica also normalised the increased levels of serum acid and alkaline phosphatase. Conclusion: The crude drug may exert anti-inflammatory activity by anti-proliferative, anti-oxidative and lysosomal membrane stabilisation


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