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Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 266-268

An interaction study of verapamil with the neuromuscular blocker gallamine

Correspondence Address:
B G Patel

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the interaction of verapamil with the neuromuscular blocking gallamine. Methods: The interaction study was carried out in rats and rabbits using inclined screen and rabbit head drop methods respectively. Results: A non-paralysing dose of gallamine (25 'g/kg) caused a quicker onset and longer duration of hind limb paralysis in rats pretreated with verapamil (5, 10 mg/kg, i.p.). A similar result was also obtained with rabbit head drop method. Twelve hours after the administration of verapamil (10 mg/kg, i.p.) the amount of gallamine required to elicit head drop in the rabbit was significantly less than that required 4 days earlier in the same rabbit without verapamil. When 5 mgkg of verapamil was used, significantly less quantities of gallamine were required at 0.5 h and 6 h intervals after verapamil injection to elicit head drop. Conclusion: It is suggested that the enhancement of action of gallamine by verapamil may be of clinical importance in patients, especially if verapamil has been taken shortly before.


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