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Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 262-265

Effect of dietary fat on tissue disposition of clofazimine in mice receiving the drug orally as suspension in oils

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A Mathur

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Objective: To evaluate the effect of dietary fats on the tissue disposition of clofazimine in mice receiving the drug orally as suspension in oil(s). Methods: Forty-five Balb/C mice were fed with either laboratory made fat-restricted diet or this diet supplemented to a fat content of 10% (w/w) with mustard oil-groundnut oil/vegetable ghee and administered clofazimine suspension in mustard oil/groundnut oil/lard oil orally at a daily dose of 50 'g for seven consecutive days. Four hours after the last daily dose the mice were sacrificed, tissues collected and clofazimine content estimated by spectrophotometric methods. Results: The drug was found accumulated in greater amounts in mesentric lymph nodes, mesentric fat, lungs, spleen, liver, kidney and small intestine and to a lesser extent in heart, muscle and tail. Most tissues from mice fed with fat-supplemented diet presented significantly more levels of clofazimine (P<0.05). The mean ˝ SD cumulative tissue clofazimine content in mice fed with fat supplemented diet ranged from 41.2 ˝ 6.38 to 43.4 ˝ 2.10 'g/g while it ranged from 34.6 ˝ 3.16 to 37.7 ˝ 2.97 'g/g in mice fed with fat restricted diet. However, the variety of oil/fat used either in the diet or drug suspensions failed to make any significant difference in drug availability in tissues. Conclusion: An extrapolation of these findings to human beings suggest that clofazimine may be administered to the patients along with or after any fatty meal for better absorption and tissue deposition.


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