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Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 255-257

Action of garlic on the hyperlipidemia of experimental induced immune complex disease in rabbits

Correspondence Address:
R C Jain

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Source of Support: None, Conflict of Interest: None

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Objective: To study the effect of garlic on hyperlipidemia in immune complex disease in rabbits. Methods: Experimental induced immune complex disease was produced in 22 albino male rabbits (1.0-l .5 kg) by injecting horse serum proteins at a dose of 175 mg/kg body weight, every 72 hours i.v., and divided into two groups. Twelve rabbits were treated with 75 mg/kg body weight garlic oil orally daily and served as test group. Ten rabbits without supplementation of garlic oil served as control group. The observation period was 4 weeks. Results: Serum complement titre was significantly decreased in test group as compared to control group (19.50(1.5 vs 2.O(0.5; P<0.001) at the end of 4th week. The total lipids, total cholesterol and beta lipoprotein cholesterol were significantly lower in test group, when compared to control groups, However, levels of triglycerides and phospholipids in test group were not significant when compared to control. Conclusion: It is observed that garlic possesses anticomplementary and hypolipidemic activity in hyperlipidemia due to induced Immune complex disease.


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