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Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 244-249

Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture

Correspondence Address:
Viswanathan Saraswathi

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Source of Support: None, Conflict of Interest: None

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Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied. Methods: Echitamine chloride at a concentration of 200'M and Vitamin A at a concentration of 10 'M were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H -Thymidine incorporation were studied. Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs. Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.


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