| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 4 | Page : 244-249
Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture
Viswanathan Saraswathi, Ramamurthy Nalini, S Subramanian, V Mathuram, S Govindasamy
Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied.
Methods: Echitamine chloride at a concentration of 200'M and Vitamin A at a concentration of 10 'M were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H -Thymidine incorporation were studied.
Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs.
Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.
Source of Support: None, Conflict of Interest: None