IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1732 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded85    
    Comments [Add]    

Recommend this journal


Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 201-203

Fear-potentiated poststartle activity in neonatal clomipramine treated rats

Correspondence Address:
J Prathiba

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To assess fear potentiated poststartle activity in adult rats administered clomipramine during neonatal period (" CLI rats"). Methods: Rat pups were treated twice daily from postnatal day 5 to 21 with clomipramine (15 mg/kg, SC). At three months of age CLI rats were given twenty trials per day, for two days. In each trial an unconditioned stimulus (US), namely footshock (0.8 mA) was presented during the last 0.5 sec of the 1 .O sec conditioned stimulus (CS), namely light. Twenty-four hours after the last conditioning trial, rats were presented with twenty alternated sequence of light-tone (98 dB) and tone-alone trials. Results: CLI rats showed an enhanced potentiated poststartle activity and increased activity in open field as compared to control rats. Conclusion: The present data suggest an increased expression of fear/anxiety in CLI rats,


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow